BDBM50290511 3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-6-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-3H-benzothiazol-2-one::CHEMBL314813

SMILES: COc1ccccc1N1CCN(CCCCc2ccc3n(CCN4CCC(CC4)C(=O)c4ccc(F)cc4)c(=O)sc3c2)CC1

InChI Key: InChIKey=QBKUPBPJZQRXGW-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50290511   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50290511 (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(CCN4CCC(CC4)C(=O)c4ccc(F)cc4)c(=O)sc3c2)CC1 Show InChI InChI=1S/C36H43FN4O3S/c1-44-33-8-3-2-7-31(33)40-23-20-38(21-24-40)17-5-4-6-27-9-14-32-34(26-27)45-36(43)41(32)25-22-39-18-15-29(16-19-39)35(42)28-10-12-30(37)13-11-28/h2-3,7-14,26,29H,4-6,15-25H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against D2 receptor in rat striatum using [3H]-Raclopride				Bioorg Med Chem Lett 7: 2579-2584 (1997) Article DOI: 10.1016/S0960-894X(97)10023-3 BindingDB Entry DOI: 10.7270/Q2QN66SR
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50290511 (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(CCN4CCC(CC4)C(=O)c4ccc(F)cc4)c(=O)sc3c2)CC1 Show InChI InChI=1S/C36H43FN4O3S/c1-44-33-8-3-2-7-31(33)40-23-20-38(21-24-40)17-5-4-6-27-9-14-32-34(26-27)45-36(43)41(32)25-22-39-18-15-29(16-19-39)35(42)28-10-12-30(37)13-11-28/h2-3,7-14,26,29H,4-6,15-25H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity for 5-hydroxytryptamine 2A receptor in rat cortex using [3H]-ketanserin				Bioorg Med Chem Lett 7: 2579-2584 (1997) Article DOI: 10.1016/S0960-894X(97)10023-3 BindingDB Entry DOI: 10.7270/Q2QN66SR
					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50290511 (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(CCN4CCC(CC4)C(=O)c4ccc(F)cc4)c(=O)sc3c2)CC1 Show InChI InChI=1S/C36H43FN4O3S/c1-44-33-8-3-2-7-31(33)40-23-20-38(21-24-40)17-5-4-6-27-9-14-32-34(26-27)45-36(43)41(32)25-22-39-18-15-29(16-19-39)35(42)28-10-12-30(37)13-11-28/h2-3,7-14,26,29H,4-6,15-25H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against Alpha-1 adrenergic receptor in rat cortex using [3H]prazosin				Bioorg Med Chem Lett 7: 2579-2584 (1997) Article DOI: 10.1016/S0960-894X(97)10023-3 BindingDB Entry DOI: 10.7270/Q2QN66SR
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50290511 (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(CCN4CCC(CC4)C(=O)c4ccc(F)cc4)c(=O)sc3c2)CC1 Show InChI InChI=1S/C36H43FN4O3S/c1-44-33-8-3-2-7-31(33)40-23-20-38(21-24-40)17-5-4-6-27-9-14-32-34(26-27)45-36(43)41(32)25-22-39-18-15-29(16-19-39)35(42)28-10-12-30(37)13-11-28/h2-3,7-14,26,29H,4-6,15-25H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampus using [3H]-8-OH-DPAT				Bioorg Med Chem Lett 7: 2579-2584 (1997) Article DOI: 10.1016/S0960-894X(97)10023-3 BindingDB Entry DOI: 10.7270/Q2QN66SR
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50290511 (3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...) Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(CCN4CCC(CC4)C(=O)c4ccc(F)cc4)c(=O)sc3c2)CC1 Show InChI InChI=1S/C36H43FN4O3S/c1-44-33-8-3-2-7-31(33)40-23-20-38(21-24-40)17-5-4-6-27-9-14-32-34(26-27)45-36(43)41(32)25-22-39-18-15-29(16-19-39)35(42)28-10-12-30(37)13-11-28/h2-3,7-14,26,29H,4-6,15-25H2,1H3	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against 5-hydroxytryptamine 2C receptor in rat choroid plexus using [3H]-N-methyl-mesulergine				Bioorg Med Chem Lett 7: 2579-2584 (1997) Article DOI: 10.1016/S0960-894X(97)10023-3 BindingDB Entry DOI: 10.7270/Q2QN66SR
					More data for this Ligand-Target Pair