BDBM50292996 2-amino-7-(furan-2-yl)-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile::CHEMBL474333

SMILES: N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccco1

InChI Key: InChIKey=BIRSEEVUVDWEDD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50292996   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50292996 (2-amino-7-(furan-2-yl)-5-oxo-4-phenyl-5,6,7,8-tetr...) Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccco1 |c:3| Show InChI InChI=1S/C20H16N2O3/c21-11-14-18(12-5-2-1-3-6-12)19-15(23)9-13(16-7-4-8-24-16)10-17(19)25-20(14)22/h1-8,13-14,18,22H,9-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells				J Med Chem 52: 912-5 (2009) Article DOI: 10.1021/jm8013458 BindingDB Entry DOI: 10.7270/Q2PV6KCP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50292996 (2-amino-7-(furan-2-yl)-5-oxo-4-phenyl-5,6,7,8-tetr...) Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccco1 |c:3| Show InChI InChI=1S/C20H16N2O3/c21-11-14-18(12-5-2-1-3-6-12)19-15(23)9-13(16-7-4-8-24-16)10-17(19)25-20(14)22/h1-8,13-14,18,22H,9-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells				J Med Chem 52: 912-5 (2009) Article DOI: 10.1021/jm8013458 BindingDB Entry DOI: 10.7270/Q2PV6KCP
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 2 (Homo sapiens (Human))	BDBM50292996 (2-amino-7-(furan-2-yl)-5-oxo-4-phenyl-5,6,7,8-tetr...) Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccco1 |c:3| Show InChI InChI=1S/C20H16N2O3/c21-11-14-18(12-5-2-1-3-6-12)19-15(23)9-13(16-7-4-8-24-16)10-17(19)25-20(14)22/h1-8,13-14,18,22H,9-10H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells				J Med Chem 52: 912-5 (2009) Article DOI: 10.1021/jm8013458 BindingDB Entry DOI: 10.7270/Q2PV6KCP
					More data for this Ligand-Target Pair