BDBM50297918 3-Chloro-N-{4-[(2R,6S)-2,6-dimethylmorpholine-4-carbonyl]benzyl}-4-fluorobenzenesulfonamide::CHEMBL552225

SMILES: C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)cc1

InChI Key: InChIKey=SQZWJDXCUYQULP-OKILXGFUSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297918   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50297918 (3-Chloro-N-{4-[(2R,6S)-2,6-dimethylmorpholine-4-ca...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C20H22ClFN2O4S/c1-13-11-24(12-14(2)28-13)20(25)16-5-3-15(4-6-16)10-23-29(26,27)17-7-8-19(22)18(21)9-17/h3-9,13-14,23H,10-12H2,1-2H3/t13-,14+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...				Bioorg Med Chem Lett 19: 4455-8 (2009) Article DOI: 10.1016/j.bmcl.2009.05.033 BindingDB Entry DOI: 10.7270/Q2VT1T1D
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50297918 (3-Chloro-N-{4-[(2R,6S)-2,6-dimethylmorpholine-4-ca...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C20H22ClFN2O4S/c1-13-11-24(12-14(2)28-13)20(25)16-5-3-15(4-6-16)10-23-29(26,27)17-7-8-19(22)18(21)9-17/h3-9,13-14,23H,10-12H2,1-2H3/t13-,14+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximi...				Bioorg Med Chem Lett 19: 4455-8 (2009) Article DOI: 10.1016/j.bmcl.2009.05.033 BindingDB Entry DOI: 10.7270/Q2VT1T1D
					More data for this Ligand-Target Pair