BDBM50299505 3 9-dihydro-N-desmethyl-N-isopropylerythromycin A::CHEMBL584549
SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C(C)C)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O
InChI Key: InChIKey=RXJCJWPPKSQMAS-IRNFSOKPSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Motilin receptor (Oryctolagus cuniculus) | BDBM50299505 (3 9-dihydro-N-desmethyl-N-isopropylerythromycin A ...) | Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 260 | n/a | n/a | n/a | n/a |
Kosan Biosciences, Inc. Curated by ChEMBL | Assay Description Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction | Bioorg Med Chem Lett 21: 3712-4 (2011) Article DOI: 10.1016/j.bmcl.2011.04.078 BindingDB Entry DOI: 10.7270/Q21J9B3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50299505 (3 9-dihydro-N-desmethyl-N-isopropylerythromycin A ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kosan Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of human ERG expressed in HEK cells | J Med Chem 52: 6851-9 (2009) Article DOI: 10.1021/jm901107f BindingDB Entry DOI: 10.7270/Q21C1XT1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Motilin receptor (Oryctolagus cuniculus) | BDBM50299505 (3 9-dihydro-N-desmethyl-N-isopropylerythromycin A ...) | Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 260 | n/a | n/a | n/a | n/a |
Kosan Biosciences, Inc. Curated by ChEMBL | Assay Description Agonist activity at motilin receptor in rabbit smooth muscle assessed as maximal possible tissue contraction | J Med Chem 52: 6851-9 (2009) Article DOI: 10.1021/jm901107f BindingDB Entry DOI: 10.7270/Q21C1XT1 | |||||||||||
More data for this Ligand-Target Pair |