null

SMILES: FCCNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(CC(F)(F)F)c2n1

InChI Key: InChIKey=VNRJYXRJFNRQRD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50300069   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50300069 (1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...) Show SMILES FCCNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(CC(F)(F)F)c2n1 Show InChI InChI=1S/C22H23F4N7O2/c23-7-8-27-21(34)29-14-3-1-13(2-4-14)18-30-19(32-10-15-5-6-16(11-32)35-15)17-9-28-33(20(17)31-18)12-22(24,25)26/h1-4,9,15-16H,5-8,10-12H2,(H2,27,29,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				J Med Chem 52: 7942-5 (2009) Article DOI: 10.1021/jm901415x BindingDB Entry DOI: 10.7270/Q2WM1DGH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50300069 (1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...) Show SMILES FCCNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(CC(F)(F)F)c2n1 Show InChI InChI=1S/C22H23F4N7O2/c23-7-8-27-21(34)29-14-3-1-13(2-4-14)18-30-19(32-10-15-5-6-16(11-32)35-15)17-9-28-33(20(17)31-18)12-22(24,25)26/h1-4,9,15-16H,5-8,10-12H2,(H2,27,29,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Flag-tagged human mTOR by DELFIA method				J Med Chem 52: 7942-5 (2009) Article DOI: 10.1021/jm901415x BindingDB Entry DOI: 10.7270/Q2WM1DGH
					More data for this Ligand-Target Pair