BDBM50300146 (R)-4-(1-Cyclopropylethyl)-6-(6-(difluoromethoxy)-2,5-dimethyl-pyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile::CHEMBL574853

SMILES: C[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O

InChI Key: InChIKey=OKVMTKHOKCHPDT-SECBINFHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300146   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM50300146 ((R)-4-(1-Cyclopropylethyl)-6-(6-(difluoromethoxy)-...) Show SMILES C[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O |r| Show InChI InChI=1S/C17H16ClF2N5O2/c1-8-12(5-11(6-21)15(22-8)27-17(19)20)23-14-16(26)25(7-13(18)24-14)9(2)10-3-4-10/h5,7,9-10,17H,3-4H2,1-2H3,(H,23,24)/t9-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenate by binding titration assay				J Med Chem 52: 7653-68 (2009) Article DOI: 10.1021/jm900716v BindingDB Entry DOI: 10.7270/Q2CN740W
					More data for this Ligand-Target Pair