BDBM50304501 6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine::CHEMBL473662

SMILES: CN1CCN(CC1)c1cc(N)nc(N)n1

InChI Key: InChIKey=RBHNSRTVBDSNLG-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50304501   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50304501 (6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine |...) Show SMILES CN1CCN(CC1)c1cc(N)nc(N)n1 Show InChI InChI=1S/C9H16N6/c1-14-2-4-15(5-3-14)8-6-7(10)12-9(11)13-8/h6H,2-5H2,1H3,(H4,10,11,12,13)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe-University Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2				Bioorg Med Chem 17: 7186-96 (2009) Article DOI: 10.1016/j.bmc.2009.08.059 BindingDB Entry DOI: 10.7270/Q2416X4F
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50304501 (6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine |...) Show SMILES CN1CCN(CC1)c1cc(N)nc(N)n1 Show InChI InChI=1S/C9H16N6/c1-14-2-4-15(5-3-14)8-6-7(10)12-9(11)13-8/h6H,2-5H2,1H3,(H4,10,11,12,13)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma				Bioorg Med Chem Lett 23: 132-7 (2012) Article DOI: 10.1016/j.bmcl.2012.10.139 BindingDB Entry DOI: 10.7270/Q28P61TF
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50304501 (6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine |...) Show SMILES CN1CCN(CC1)c1cc(N)nc(N)n1 Show InChI InChI=1S/C9H16N6/c1-14-2-4-15(5-3-14)8-6-7(10)12-9(11)13-8/h6H,2-5H2,1H3,(H4,10,11,12,13)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 23: 132-7 (2012) Article DOI: 10.1016/j.bmcl.2012.10.139 BindingDB Entry DOI: 10.7270/Q28P61TF
					More data for this Ligand-Target Pair