BDBM50304956 CHEMBL592754::N-(2-hydroxy-2-(thiophen-2-yl)ethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide

SMILES: Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1cccs1

InChI Key: InChIKey=DXJDBXBFXWUNBP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50304956   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acyl-CoA desaturase 1 (Mus musculus)	BDBM50304956 (CHEMBL592754 | N-(2-hydroxy-2-(thiophen-2-yl)ethyl...) Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1cccs1 Show InChI InChI=1S/C24H26N4O3S/c1-16-5-2-3-6-18(16)23(30)17-10-12-28(13-11-17)22-9-8-19(26-27-22)24(31)25-15-20(29)21-7-4-14-32-21/h2-9,14,17,20,29H,10-13,15H2,1H3,(H,25,31)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 mins				Bioorg Med Chem Lett 20: 341-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7
					More data for this Ligand-Target Pair
Stearoyl-CoA desaturase 1 (Homo sapiens (Human))	BDBM50304956 (CHEMBL592754 | N-(2-hydroxy-2-(thiophen-2-yl)ethyl...) Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1cccs1 Show InChI InChI=1S/C24H26N4O3S/c1-16-5-2-3-6-18(16)23(30)17-10-12-28(13-11-17)22-9-8-19(26-27-22)24(31)25-15-20(29)21-7-4-14-32-21/h2-9,14,17,20,29H,10-13,15H2,1H3,(H,25,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of human Scd1 expressed in HEK-293A cells assessed as conversion of [14C]stearate to [14C]oleate pretreated for 30 mins measured after 4 h...				Bioorg Med Chem Lett 20: 341-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7
					More data for this Ligand-Target Pair
Stearoyl-CoA desaturase 1 (Homo sapiens (Human))	BDBM50304956 (CHEMBL592754 | N-(2-hydroxy-2-(thiophen-2-yl)ethyl...) Show SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1cccs1 Show InChI InChI=1S/C24H26N4O3S/c1-16-5-2-3-6-18(16)23(30)17-10-12-28(13-11-17)22-9-8-19(26-27-22)24(31)25-15-20(29)21-7-4-14-32-21/h2-9,14,17,20,29H,10-13,15H2,1H3,(H,25,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co. Ltd Curated by ChEMBL					Assay Description Inhibition of Scd1 in human HEK-293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 ...				Bioorg Med Chem Lett 20: 341-5 (2010) Article DOI: 10.1016/j.bmcl.2009.10.101 BindingDB Entry DOI: 10.7270/Q23X86R7
					More data for this Ligand-Target Pair