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SMILES: Fc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1

InChI Key: InChIKey=UBHBMONOIRNUJF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305174   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50305174
PNG
(9-(2,4-difluorophenyl)-8,12,14-triazatetracyclo[8....)
Show SMILES Fc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1
Show InChI InChI=1S/C20H13F2N3/c21-11-5-6-14(16(22)9-11)19-15-10-24-20-18(15)13(7-8-23-20)12-3-1-2-4-17(12)25-19/h1-10,19,25H,(H,23,24)
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 210n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 by radiometric assay

Bioorg Med Chem Lett 20: 153-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.021
BindingDB Entry DOI: 10.7270/Q2PN95RQ
More data for this
Ligand-Target Pair