BDBM50305487 8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)quinoline-3-carboxamide::CHEMBL593267

SMILES: CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(cnc3c(Cl)cccc23)C(N)=O)c1

InChI Key: InChIKey=AIOWJRXDKURKOW-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50305487   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50305487 (8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)qu...) Show SMILES CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(cnc3c(Cl)cccc23)C(N)=O)c1 Show InChI InChI=1S/C23H17ClN2O4S/c1-31(28,29)17-8-3-7-16(12-17)30-15-6-2-5-14(11-15)21-18-9-4-10-20(24)22(18)26-13-19(21)23(25)27/h2-13H,1H3,(H2,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method				Bioorg Med Chem Lett 20: 689-93 (2010) Article DOI: 10.1016/j.bmcl.2009.11.062 BindingDB Entry DOI: 10.7270/Q2W66KV8
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50305487 (8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)qu...) Show SMILES CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(cnc3c(Cl)cccc23)C(N)=O)c1 Show InChI InChI=1S/C23H17ClN2O4S/c1-31(28,29)17-8-3-7-16(12-17)30-15-6-2-5-14(11-15)21-18-9-4-10-20(24)22(18)26-13-19(21)23(25)27/h2-13H,1H3,(H2,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	543	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate method				Bioorg Med Chem Lett 20: 689-93 (2010) Article DOI: 10.1016/j.bmcl.2009.11.062 BindingDB Entry DOI: 10.7270/Q2W66KV8
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50305487 (8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)qu...) Show SMILES CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(cnc3c(Cl)cccc23)C(N)=O)c1 Show InChI InChI=1S/C23H17ClN2O4S/c1-31(28,29)17-8-3-7-16(12-17)30-15-6-2-5-14(11-15)21-18-9-4-10-20(24)22(18)26-13-19(21)23(25)27/h2-13H,1H3,(H2,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human LXRalpha ligand binding domain expressed in human HuH7 cells co-transfected with Gal4-DBD by transactivation assay				Bioorg Med Chem Lett 20: 689-93 (2010) Article DOI: 10.1016/j.bmcl.2009.11.062 BindingDB Entry DOI: 10.7270/Q2W66KV8
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50305487 (8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)qu...) Show SMILES CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(cnc3c(Cl)cccc23)C(N)=O)c1 Show InChI InChI=1S/C23H17ClN2O4S/c1-31(28,29)17-8-3-7-16(12-17)30-15-6-2-5-14(11-15)21-18-9-4-10-20(24)22(18)26-13-19(21)23(25)27/h2-13H,1H3,(H2,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	630	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta ligand binding domain expressed in human HuH7 cells co-transfected with Gal4-DBD by transactivation assay				Bioorg Med Chem Lett 20: 689-93 (2010) Article DOI: 10.1016/j.bmcl.2009.11.062 BindingDB Entry DOI: 10.7270/Q2W66KV8
					More data for this Ligand-Target Pair