BDBM50307137 (3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one::(Z)-5-Amino-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one::CHEMBL597181

SMILES: Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1

InChI Key: InChIKey=XYONNOXYJMPBMA-GHXNOFRVSA-N

Data: 4 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50307137   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50307137 ((3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methy...) Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1 Show InChI InChI=1S/C15H15N3O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,16H2,1-2H3,(H,18,19)/b12-7-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano-Bicocca Curated by ChEMBL					Assay Description Inhibition of FLT3 by ELISA-based kinase assay				Bioorg Med Chem 18: 1482-96 (2010) Article DOI: 10.1016/j.bmc.2010.01.011 BindingDB Entry DOI: 10.7270/Q2B56KPQ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50307137 ((3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methy...) Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1 Show InChI InChI=1S/C15H15N3O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,16H2,1-2H3,(H,18,19)/b12-7-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano-Bicocca Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells				Bioorg Med Chem 18: 1482-96 (2010) Article DOI: 10.1016/j.bmc.2010.01.011 BindingDB Entry DOI: 10.7270/Q2B56KPQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50307137 ((3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methy...) Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1 Show InChI InChI=1S/C15H15N3O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,16H2,1-2H3,(H,18,19)/b12-7-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano-Bicocca Curated by ChEMBL					Assay Description Inhibition of ALK by ELISA-based kinase assay				Bioorg Med Chem 18: 1482-96 (2010) Article DOI: 10.1016/j.bmc.2010.01.011 BindingDB Entry DOI: 10.7270/Q2B56KPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50307137 ((3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methy...) Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1 Show InChI InChI=1S/C15H15N3O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,16H2,1-2H3,(H,18,19)/b12-7-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano-Bicocca Curated by ChEMBL					Assay Description Inhibition of ABL by ELISA-based kinase assay				Bioorg Med Chem 18: 1482-96 (2010) Article DOI: 10.1016/j.bmc.2010.01.011 BindingDB Entry DOI: 10.7270/Q2B56KPQ
					More data for this Ligand-Target Pair