BDBM50308002 1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-phenylpiperazine::CHEMBL597601
SMILES: Clc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)cn1
InChI Key: InChIKey=MHJWMIITIMUUKU-UHFFFAOYSA-N
Data: 16 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio Grande do Sul Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate | Bioorg Med Chem 18: 1925-35 (2010) Article DOI: 10.1016/j.bmc.2010.01.040 BindingDB Entry DOI: 10.7270/Q2S75H99 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Goi£s Curated by ChEMBL | Assay Description Displacement of [3H]-YM-09151-2 from human D4 dopamine receptor after 120 mins by liquid scintillation counting | Eur J Med Chem 62: 214-21 (2013) Article DOI: 10.1016/j.ejmech.2012.08.011 BindingDB Entry DOI: 10.7270/Q2QZ2CBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro Curated by ChEMBL | Assay Description Displacement of [3H]-YM-09151-2 from human D4 receptor after 120 mins by liquid scintillation counting | Eur J Med Chem 66: 122-34 (2013) Article DOI: 10.1016/j.ejmech.2013.05.027 BindingDB Entry DOI: 10.7270/Q2514253 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Goi£s Curated by ChEMBL | Assay Description Displacement of [3H]-OH-8-DPAT from 5HT1A receptor in Wistar rat hippocampal membrane after 15 mins by liquid scintillation counting | Eur J Med Chem 62: 214-21 (2013) Article DOI: 10.1016/j.ejmech.2012.08.011 BindingDB Entry DOI: 10.7270/Q2QZ2CBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat brain hippocampal membranes after 15 mins by liquid scintillation counting | Eur J Med Chem 66: 122-34 (2013) Article DOI: 10.1016/j.ejmech.2013.05.027 BindingDB Entry DOI: 10.7270/Q2514253 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Goi£s Curated by ChEMBL | Assay Description Displacement of [3H]-YM-09151-2 from D2 dopamine receptor in Wistar rat brain striatal membrane after 60 mins by liquid scintillation counting | Eur J Med Chem 62: 214-21 (2013) Article DOI: 10.1016/j.ejmech.2012.08.011 BindingDB Entry DOI: 10.7270/Q2QZ2CBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro Curated by ChEMBL | Assay Description Displacement of [3H]-YM-09151-2 from D2 receptor in rat brain striatal membranes after 60 mins by liquid scintillation counting | Eur J Med Chem 66: 122-34 (2013) Article DOI: 10.1016/j.ejmech.2013.05.027 BindingDB Entry DOI: 10.7270/Q2514253 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio Grande do Sul Curated by ChEMBL | Assay Description Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate | Bioorg Med Chem 18: 1925-35 (2010) Article DOI: 10.1016/j.bmc.2010.01.040 BindingDB Entry DOI: 10.7270/Q2S75H99 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Goi£s Curated by ChEMBL | Assay Description Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting | Eur J Med Chem 62: 214-21 (2013) Article DOI: 10.1016/j.ejmech.2012.08.011 BindingDB Entry DOI: 10.7270/Q2QZ2CBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro Curated by ChEMBL | Assay Description Displacement of [3H]-RX821002 from alpha2 adrenoreceptor in rat brain cortical membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 66: 122-34 (2013) Article DOI: 10.1016/j.ejmech.2013.05.027 BindingDB Entry DOI: 10.7270/Q2514253 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha adrenergic receptor 1A and 1B (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro Curated by ChEMBL | Assay Description Displacement of [3H]-prozosin from alpha1B adrenoreceptor in rat liver membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 66: 122-34 (2013) Article DOI: 10.1016/j.ejmech.2013.05.027 BindingDB Entry DOI: 10.7270/Q2514253 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha adrenergic receptor 1A and 1B (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Goi£s Curated by ChEMBL | Assay Description Displacement of [3H]-prazosin from alpha1B adrenergic receptor in Wistar rat liver membrane after 45 mins by liquid scintillation counting | Eur J Med Chem 62: 214-21 (2013) Article DOI: 10.1016/j.ejmech.2012.08.011 BindingDB Entry DOI: 10.7270/Q2QZ2CBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Goi£s Curated by ChEMBL | Assay Description Displacement of [3H]-ketanserin from 5HT2A receptor in Wistar rat cortical membrane after 15 mins by liquid scintillation counting | Eur J Med Chem 62: 214-21 (2013) Article DOI: 10.1016/j.ejmech.2012.08.011 BindingDB Entry DOI: 10.7270/Q2QZ2CBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro Curated by ChEMBL | Assay Description Displacement of [3H]-ketanserin from 5HT2A receptor in rat brain cortical membranes after 15 mins by liquid scintillation counting | Eur J Med Chem 66: 122-34 (2013) Article DOI: 10.1016/j.ejmech.2013.05.027 BindingDB Entry DOI: 10.7270/Q2514253 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Goi£s Curated by ChEMBL | Assay Description Displacement of [3H]-mesulergine from human 5HT2C receptor after 60 mins by liquid scintillation counting | Eur J Med Chem 62: 214-21 (2013) Article DOI: 10.1016/j.ejmech.2012.08.011 BindingDB Entry DOI: 10.7270/Q2QZ2CBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50308002 (1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-p...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro Curated by ChEMBL | Assay Description Displacement of [3H]-mesulergine from human 5HT2C receptor after 60 mins by liquid scintillation counting | Eur J Med Chem 66: 122-34 (2013) Article DOI: 10.1016/j.ejmech.2013.05.027 BindingDB Entry DOI: 10.7270/Q2514253 | |||||||||||
More data for this Ligand-Target Pair |