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SMILES: ONC(=O)COc1ccc2C[C@H](NCc2c1)C(=O)NCCc1ccccc1

InChI Key: InChIKey=TVMFVKUPHBKWIP-SFHVURJKSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308289   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50308289
PNG
((S)-7-(2-(Hydroxyamino)-2-oxoethoxy)-N-phenethyl-1...)
Show SMILES ONC(=O)COc1ccc2C[C@H](NCc2c1)C(=O)NCCc1ccccc1 |r|
Show InChI InChI=1S/C20H23N3O4/c24-19(23-26)13-27-17-7-6-15-11-18(22-12-16(15)10-17)20(25)21-9-8-14-4-2-1-3-5-14/h1-7,10,18,22,26H,8-9,11-13H2,(H,21,25)(H,23,24)/t18-/m0/s1
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Similars
Article
PubMed
n/an/a 4.07E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 expressed in Escherichia coli assessed as Boc-Lys (acetyl)-AMC substrate hydrolysis by fluorimetric assay

Bioorg Med Chem 18: 1761-72 (2010)


Article DOI: 10.1016/j.bmc.2010.01.060
BindingDB Entry DOI: 10.7270/Q2JD4WX3
More data for this
Ligand-Target Pair