BDBM50310363 3-(2'-Pyridinyl)-1H-naphtho[2,1-b]pyran-1-one::CHEMBL599551
SMILES: O=c1cc(oc2ccc3ccccc3c12)-c1ccccn1
InChI Key: InChIKey=ZTEHSCMHCBKLIH-UHFFFAOYSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aryl hydrocarbon receptor (Homo sapiens (Human)) | BDBM50310363 (3-(2'-Pyridinyl)-1H-naphtho[2,1-b]pyran-1-one | CH...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Agonist activity at AhR in human MCF-7 cells assessed as increase of CYP1A1-dependent 7-ethoxyresorufin O-deethylase activity | J Med Chem 54: 1539-54 (2011) Article DOI: 10.1021/jm101356p BindingDB Entry DOI: 10.7270/Q27S7P30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aryl hydrocarbon receptor (Homo sapiens (Human)) | BDBM50310363 (3-(2'-Pyridinyl)-1H-naphtho[2,1-b]pyran-1-one | CH...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Agonist activity at aryl hydrocarbon receptor in human MCF7 cells after 24 hrs CYP1A1-dependent EROD assay | Bioorg Med Chem 18: 1194-203 (2010) Article DOI: 10.1016/j.bmc.2009.12.036 BindingDB Entry DOI: 10.7270/Q2GX4BNF | |||||||||||
More data for this Ligand-Target Pair |