BDBM50310470 4-(5-amino-1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine::CHEMBL1080071
SMILES: Nc1nonc1-c1nc2cc(N)ccc2n1C1CCC1
InChI Key: InChIKey=KKSLZAWDUQRHLJ-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human)) | BDBM50310470 (4-(5-amino-1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence of | Bioorg Med Chem Lett 19: 5191-4 (2009) Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50310470 (4-(5-amino-1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence of | Bioorg Med Chem Lett 19: 5191-4 (2009) Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM50310470 (4-(5-amino-1-cyclobutyl-1H-benzo[d]imidazol-2-yl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of GSK3beta assessed as decrease in NADH absorbance at 340 nm in the presence of | Bioorg Med Chem Lett 19: 5191-4 (2009) Article DOI: 10.1016/j.bmcl.2009.07.022 BindingDB Entry DOI: 10.7270/Q2KP8287 | |||||||||||
More data for this Ligand-Target Pair |