BDBM50311083 (1S,2R)-1-(5-(4-chloro-1H-pyrazol-1-yl)thiophene-2-sulfonamido)-2-phenylcyclopropanecarboxylic acid::CHEMBL1077893::US10322143, Shiozaki Ciompound 9
SMILES: OC(=O)[C@@]1(C[C@@H]1c1ccccc1)NS(=O)(=O)c1ccc(s1)-n1cc(Cl)cn1
InChI Key: InChIKey=RZNLKLDILSYSNA-DYVFJYSZSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human)) | BDBM50311083 ((1S,2R)-1-(5-(4-chloro-1H-pyrazol-1-yl)thiophene-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ... | Bioorg Med Chem Lett 19: 4280-3 (2009) BindingDB Entry DOI: 10.7270/Q2BC41VN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human)) | BDBM50311083 ((1S,2R)-1-(5-(4-chloro-1H-pyrazol-1-yl)thiophene-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of ADAMTS5 | Bioorg Med Chem Lett 19: 6213-7 (2009) Article DOI: 10.1016/j.bmcl.2009.08.093 BindingDB Entry DOI: 10.7270/Q2ZS2WMT | |||||||||||
More data for this Ligand-Target Pair |