BDBM50311890 3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-m-tolylbenzamide::CHEMBL1076194

SMILES: CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(ccc2C)C(=O)Nc2cccc(C)c2)nc2ccccc12

InChI Key: InChIKey=BDUYLUFNRITWFA-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50311890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50311890 (3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-y...) Show SMILES CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(ccc2C)C(=O)Nc2cccc(C)c2)nc2ccccc12 Show InChI InChI=1S/C32H36N8O/c1-22-10-9-11-25(18-22)36-31(41)24-15-14-23(2)27(19-24)38-32-37-26-12-5-6-13-28(26)40(32)30-20-29(34-21-35-30)33-16-7-8-17-39(3)4/h5-6,9-15,18-21H,7-8,16-17H2,1-4H3,(H,36,41)(H,37,38)(H,33,34,35)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	531	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused LCK expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50311890 (3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-y...) Show SMILES CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(ccc2C)C(=O)Nc2cccc(C)c2)nc2ccccc12 Show InChI InChI=1S/C32H36N8O/c1-22-10-9-11-25(18-22)36-31(41)24-15-14-23(2)27(19-24)38-32-37-26-12-5-6-13-28(26)40(32)30-20-29(34-21-35-30)33-16-7-8-17-39(3)4/h5-6,9-15,18-21H,7-8,16-17H2,1-4H3,(H,36,41)(H,37,38)(H,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused InsR expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50311890 (3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-y...) Show SMILES CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(ccc2C)C(=O)Nc2cccc(C)c2)nc2ccccc12 Show InChI InChI=1S/C32H36N8O/c1-22-10-9-11-25(18-22)36-31(41)24-15-14-23(2)27(19-24)38-32-37-26-12-5-6-13-28(26)40(32)30-20-29(34-21-35-30)33-16-7-8-17-39(3)4/h5-6,9-15,18-21H,7-8,16-17H2,1-4H3,(H,36,41)(H,37,38)(H,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused LYN expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50311890 (3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-y...) Show SMILES CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(ccc2C)C(=O)Nc2cccc(C)c2)nc2ccccc12 Show InChI InChI=1S/C32H36N8O/c1-22-10-9-11-25(18-22)36-31(41)24-15-14-23(2)27(19-24)38-32-37-26-12-5-6-13-28(26)40(32)30-20-29(34-21-35-30)33-16-7-8-17-39(3)4/h5-6,9-15,18-21H,7-8,16-17H2,1-4H3,(H,36,41)(H,37,38)(H,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused KDR expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50311890 (3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-y...) Show SMILES CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(ccc2C)C(=O)Nc2cccc(C)c2)nc2ccccc12 Show InChI InChI=1S/C32H36N8O/c1-22-10-9-11-25(18-22)36-31(41)24-15-14-23(2)27(19-24)38-32-37-26-12-5-6-13-28(26)40(32)30-20-29(34-21-35-30)33-16-7-8-17-39(3)4/h5-6,9-15,18-21H,7-8,16-17H2,1-4H3,(H,36,41)(H,37,38)(H,33,34,35)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused LCK expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50311890 (3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-y...) Show SMILES CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(ccc2C)C(=O)Nc2cccc(C)c2)nc2ccccc12 Show InChI InChI=1S/C32H36N8O/c1-22-10-9-11-25(18-22)36-31(41)24-15-14-23(2)27(19-24)38-32-37-26-12-5-6-13-28(26)40(32)30-20-29(34-21-35-30)33-16-7-8-17-39(3)4/h5-6,9-15,18-21H,7-8,16-17H2,1-4H3,(H,36,41)(H,37,38)(H,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused SRC expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM50311890 (3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-y...) Show SMILES CN(C)CCCCNc1cc(ncn1)-n1c(Nc2cc(ccc2C)C(=O)Nc2cccc(C)c2)nc2ccccc12 Show InChI InChI=1S/C32H36N8O/c1-22-10-9-11-25(18-22)36-31(41)24-15-14-23(2)27(19-24)38-32-37-26-12-5-6-13-28(26)40(32)30-20-29(34-21-35-30)33-16-7-8-17-39(3)4/h5-6,9-15,18-21H,7-8,16-17H2,1-4H3,(H,36,41)(H,37,38)(H,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of HCK				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair