BDBM50311899 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-(difluoromethoxy)phenyl)-4-methylbenzamide::CHEMBL1088027

SMILES: Cc1ccc(cc1Nc1nc2ccccc2n1-c1cc(N)ncn1)C(=O)Nc1cccc(OC(F)F)c1

InChI Key: InChIKey=GLDQJVYQRVZJIH-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50311899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin receptor (Homo sapiens (Human))	BDBM50311899 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES Cc1ccc(cc1Nc1nc2ccccc2n1-c1cc(N)ncn1)C(=O)Nc1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H21F2N7O2/c1-15-9-10-16(24(36)32-17-5-4-6-18(12-17)37-25(27)28)11-20(15)34-26-33-19-7-2-3-8-21(19)35(26)23-13-22(29)30-14-31-23/h2-14,25H,1H3,(H,32,36)(H,33,34)(H2,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused InsR expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50311899 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES Cc1ccc(cc1Nc1nc2ccccc2n1-c1cc(N)ncn1)C(=O)Nc1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H21F2N7O2/c1-15-9-10-16(24(36)32-17-5-4-6-18(12-17)37-25(27)28)11-20(15)34-26-33-19-7-2-3-8-21(19)35(26)23-13-22(29)30-14-31-23/h2-14,25H,1H3,(H,32,36)(H,33,34)(H2,29,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused LCK expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM50311899 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES Cc1ccc(cc1Nc1nc2ccccc2n1-c1cc(N)ncn1)C(=O)Nc1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H21F2N7O2/c1-15-9-10-16(24(36)32-17-5-4-6-18(12-17)37-25(27)28)11-20(15)34-26-33-19-7-2-3-8-21(19)35(26)23-13-22(29)30-14-31-23/h2-14,25H,1H3,(H,32,36)(H,33,34)(H2,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of HCK				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50311899 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES Cc1ccc(cc1Nc1nc2ccccc2n1-c1cc(N)ncn1)C(=O)Nc1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H21F2N7O2/c1-15-9-10-16(24(36)32-17-5-4-6-18(12-17)37-25(27)28)11-20(15)34-26-33-19-7-2-3-8-21(19)35(26)23-13-22(29)30-14-31-23/h2-14,25H,1H3,(H,32,36)(H,33,34)(H2,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused KDR expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50311899 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES Cc1ccc(cc1Nc1nc2ccccc2n1-c1cc(N)ncn1)C(=O)Nc1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H21F2N7O2/c1-15-9-10-16(24(36)32-17-5-4-6-18(12-17)37-25(27)28)11-20(15)34-26-33-19-7-2-3-8-21(19)35(26)23-13-22(29)30-14-31-23/h2-14,25H,1H3,(H,32,36)(H,33,34)(H2,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused LYN expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50311899 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES Cc1ccc(cc1Nc1nc2ccccc2n1-c1cc(N)ncn1)C(=O)Nc1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H21F2N7O2/c1-15-9-10-16(24(36)32-17-5-4-6-18(12-17)37-25(27)28)11-20(15)34-26-33-19-7-2-3-8-21(19)35(26)23-13-22(29)30-14-31-23/h2-14,25H,1H3,(H,32,36)(H,33,34)(H2,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused SRC expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50311899 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES Cc1ccc(cc1Nc1nc2ccccc2n1-c1cc(N)ncn1)C(=O)Nc1cccc(OC(F)F)c1 Show InChI InChI=1S/C26H21F2N7O2/c1-15-9-10-16(24(36)32-17-5-4-6-18(12-17)37-25(27)28)11-20(15)34-26-33-19-7-2-3-8-21(19)35(26)23-13-22(29)30-14-31-23/h2-14,25H,1H3,(H,32,36)(H,33,34)(H2,29,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused LCK expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair