BDBM50311903 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-methoxyphenyl)-4-methylbenzamide::CHEMBL1081090

SMILES: COc1cccc(NC(=O)c2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1

InChI Key: InChIKey=DXZISSBXMPGCOF-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50311903   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50311903 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES COc1cccc(NC(=O)c2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1 Show InChI InChI=1S/C26H23N7O2/c1-16-10-11-17(25(34)30-18-6-5-7-19(13-18)35-2)12-21(16)32-26-31-20-8-3-4-9-22(20)33(26)24-14-23(27)28-15-29-24/h3-15H,1-2H3,(H,30,34)(H,31,32)(H2,27,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of LCK				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50311903 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES COc1cccc(NC(=O)c2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1 Show InChI InChI=1S/C26H23N7O2/c1-16-10-11-17(25(34)30-18-6-5-7-19(13-18)35-2)12-21(16)32-26-31-20-8-3-4-9-22(20)33(26)24-14-23(27)28-15-29-24/h3-15H,1-2H3,(H,30,34)(H,31,32)(H2,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused InsR expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM50311903 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES COc1cccc(NC(=O)c2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1 Show InChI InChI=1S/C26H23N7O2/c1-16-10-11-17(25(34)30-18-6-5-7-19(13-18)35-2)12-21(16)32-26-31-20-8-3-4-9-22(20)33(26)24-14-23(27)28-15-29-24/h3-15H,1-2H3,(H,30,34)(H,31,32)(H2,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of HCK				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50311903 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES COc1cccc(NC(=O)c2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1 Show InChI InChI=1S/C26H23N7O2/c1-16-10-11-17(25(34)30-18-6-5-7-19(13-18)35-2)12-21(16)32-26-31-20-8-3-4-9-22(20)33(26)24-14-23(27)28-15-29-24/h3-15H,1-2H3,(H,30,34)(H,31,32)(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	516	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused KDR expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50311903 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES COc1cccc(NC(=O)c2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1 Show InChI InChI=1S/C26H23N7O2/c1-16-10-11-17(25(34)30-18-6-5-7-19(13-18)35-2)12-21(16)32-26-31-20-8-3-4-9-22(20)33(26)24-14-23(27)28-15-29-24/h3-15H,1-2H3,(H,30,34)(H,31,32)(H2,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	437	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused LYN expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50311903 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES COc1cccc(NC(=O)c2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1 Show InChI InChI=1S/C26H23N7O2/c1-16-10-11-17(25(34)30-18-6-5-7-19(13-18)35-2)12-21(16)32-26-31-20-8-3-4-9-22(20)33(26)24-14-23(27)28-15-29-24/h3-15H,1-2H3,(H,30,34)(H,31,32)(H2,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused SRC expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50311903 (3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...) Show SMILES COc1cccc(NC(=O)c2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)c1 Show InChI InChI=1S/C26H23N7O2/c1-16-10-11-17(25(34)30-18-6-5-7-19(13-18)35-2)12-21(16)32-26-31-20-8-3-4-9-22(20)33(26)24-14-23(27)28-15-29-24/h3-15H,1-2H3,(H,30,34)(H,31,32)(H2,27,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Tel-fused LCK expressed in mouse BAF3 cells				Bioorg Med Chem Lett 19: 6691-5 (2009) Article DOI: 10.1016/j.bmcl.2009.09.123 BindingDB Entry DOI: 10.7270/Q2Q52PRR
					More data for this Ligand-Target Pair