BindingDB PrimarySearch

BDBM50312526 CHEMBL1076754::N-Butyl-L-ido-1-deoxynojirimycin

SMILES: CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO

InChI Key: InChIKey=UQRORFVVSGFNRO-AXTSPUMRSA-N

Data: 15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50312526
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sucrase-isomaltase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of sucrase by HPLC				J Med Chem 53: 689-98 (2010) Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-glucosidase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant GBA2 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay				ACS Med Chem Lett 2: 119-123 (2011) Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-glucosidase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of GBA2 (unknown origin)				J Med Chem 57: 9096-104 (2014) Article DOI: 10.1021/jm501181z BindingDB Entry DOI: 10.7270/Q20003PT
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of GCS by cell-based assay				J Med Chem 53: 689-98 (2010) Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Lactase-phlorizin hydrolase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of lactase by HPLC				J Med Chem 53: 689-98 (2010) Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-glucosidase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of GBA2 by HPLC				J Med Chem 53: 689-98 (2010) Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Lysosomal alpha-glucosidase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of lysosomal alpha-glucosidase by HPLC				J Med Chem 53: 689-98 (2010) Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen debranching enzyme (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of glycogen glycogen de-branching enzyme by HPLC				J Med Chem 53: 689-98 (2010) Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Maltase-glucoamylase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of maltase by HPLC				J Med Chem 53: 689-98 (2010) Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair
Lysosomal acid glucosylceramidase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay				ACS Med Chem Lett 2: 119-123 (2011) Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Ceramide glucosyltransferase (Mus musculus)	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay				ACS Med Chem Lett 2: 119-123 (2011) Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
alpha-glucosidase (Gaa) (Mus musculus (Mouse))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of maltase in mouse intestinal input by glucose release assay				ACS Med Chem Lett 2: 119-123 (2011) Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-galactosidase (Mus musculus)	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of lactase in mouse intestinal input by glucose release assay				ACS Med Chem Lett 2: 119-123 (2011) Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Sucrase-isomaltase (Mus musculus)	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of sucrase in mouse intestinal input by glucose release assay				ACS Med Chem Lett 2: 119-123 (2011) Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Ceramide glucosyltransferase (Homo sapiens (Human))	BDBM50312526 (CHEMBL1076754 \| N-Butyl-L-ido-1-deoxynojirimycin) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide				J Med Chem 57: 9096-104 (2014) Article DOI: 10.1021/jm501181z BindingDB Entry DOI: 10.7270/Q20003PT
Leiden University Curated by ChEMBL					More data for this Ligand-Target Pair