BDBM50313053 (Z)-4-(2-(4-(dimethylamino)phenyl)hydrazono)-3-(4-methoxyphenyl)-1H-pyrazol-5(4H)-one::CHEMBL1081070

SMILES: COc1ccc(cc1)-c1[nH][nH]c(=O)c1N=Nc1ccc(cc1)N(C)C

InChI Key: InChIKey=WRYFIMLFEYFYRU-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50313053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50313053 ((Z)-4-(2-(4-(dimethylamino)phenyl)hydrazono)-3-(4-...) Show SMILES COc1ccc(cc1)-c1[nH][nH]c(=O)c1N=Nc1ccc(cc1)N(C)C |w:14.15| Show InChI InChI=1S/C18H19N5O2/c1-23(2)14-8-6-13(7-9-14)19-21-17-16(20-22-18(17)24)12-4-10-15(25-3)11-5-12/h4-11H,1-3H3,(H2,20,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of GSK3-beta assessed as NADH level after 10 mins by pyruvate kinase/lactate dehydrogenase coupled spectrophotometric assay				Bioorg Med Chem Lett 20: 1661-4 (2010) Article DOI: 10.1016/j.bmcl.2010.01.072 BindingDB Entry DOI: 10.7270/Q2TX3G9B
					More data for this Ligand-Target Pair