BDBM50313473 4-cycloheptyl-6-propylpyrimidine-2-carbonitrile::CHEMBL1085423
SMILES: CCCc1cc(nc(n1)C#N)C1CCCCCC1
InChI Key: InChIKey=UOAUUFFKQMFGTJ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cathepsin S (Homo sapiens (Human)) | BDBM50313473![]() (4-cycloheptyl-6-propylpyrimidine-2-carbonitrile | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation Curated by ChEMBL | Assay Description Inhibition of human recombinant cathepsin S by fluorescence assay | Bioorg Med Chem Lett 20: 1524-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.100 BindingDB Entry DOI: 10.7270/Q24X57ZH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin K (Homo sapiens (Human)) | BDBM50313473![]() (4-cycloheptyl-6-propylpyrimidine-2-carbonitrile | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation Curated by ChEMBL | Assay Description Inhibition of human recombinant cathepsin K by fluorescence assay | Bioorg Med Chem Lett 20: 1524-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.100 BindingDB Entry DOI: 10.7270/Q24X57ZH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) |