BindingDB PrimarySearch

BDBM50313604 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3-oxime::CHEMBL1077291

SMILES: Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O

InChI Key: InChIKey=XEIDGVAXPPRCTD-UHFFFAOYSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50313604
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase 17B (STK17B) (Homo sapiens (Human))	BDBM50313604 (5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3...) Show SMILES Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay				Bioorg Med Chem Lett 26: 2719-23 (2016) Article DOI: 10.1016/j.bmcl.2016.03.111 BindingDB Entry DOI: 10.7270/Q2N29ZTZ
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50313604 (5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3...) Show SMILES Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of Aurora A by HTRF assay				Bioorg Med Chem Lett 20: 2033-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.039 BindingDB Entry DOI: 10.7270/Q29W0GF0
Institute of Science and Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50313604 (5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3...) Show SMILES Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of insulin receptor by HTRF assay				Bioorg Med Chem Lett 20: 2033-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.039 BindingDB Entry DOI: 10.7270/Q29W0GF0
Institute of Science and Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50313604 (5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3...) Show SMILES Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				Bioorg Med Chem Lett 20: 2033-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.039 BindingDB Entry DOI: 10.7270/Q29W0GF0
Institute of Science and Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50313604 (5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3...) Show SMILES Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of Ron by HTRF assay				Bioorg Med Chem Lett 20: 2033-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.039 BindingDB Entry DOI: 10.7270/Q29W0GF0
Institute of Science and Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50313604 (5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3...) Show SMILES Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of Met by HTRF assay				Bioorg Med Chem Lett 20: 2033-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.039 BindingDB Entry DOI: 10.7270/Q29W0GF0
Institute of Science and Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50313604 (5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3...) Show SMILES Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of VEGFR2 by HTRF assay				Bioorg Med Chem Lett 20: 2033-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.039 BindingDB Entry DOI: 10.7270/Q29W0GF0
Institute of Science and Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50313604 (5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'-dione 3...) Show SMILES Fc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of EGFR by HTRF assay				Bioorg Med Chem Lett 20: 2033-7 (2010) Article DOI: 10.1016/j.bmcl.2010.01.039 BindingDB Entry DOI: 10.7270/Q29W0GF0
Institute of Science and Technology Curated by ChEMBL					More data for this Ligand-Target Pair