BDBM50313860 (R)-5-chloro-1-(1-cyclopropylethyl)-3-(6-(dimethylamino)-2,5-dimethylpyridin-3-ylamino)pyrazin-2(1H)-one::CHEMBL1084423
SMILES: C[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(nc2C)N(C)C)c1=O
InChI Key: InChIKey=WFAWSQOYHNWGQF-GFCCVEGCSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corticotropin releasing factor receptor (Rattus norvegicus (rat)) | BDBM50313860 ((R)-5-chloro-1-(1-cyclopropylethyl)-3-(6-(dimethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate by gamma counting | Bioorg Med Chem Lett 20: 1890-4 (2010) Article DOI: 10.1016/j.bmcl.2010.01.129 BindingDB Entry DOI: 10.7270/Q29G5MZ4 | |||||||||||
More data for this Ligand-Target Pair |