BDBM50316922 (R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-yl)-N,N-dimethylpyrrolidin-3-amine::CHEMBL1087367

SMILES: COc1ccc(Cn2c(nc3ccccc23)N2CC[C@H](C2)N(C)C)cc1

InChI Key: InChIKey=ZCRCTVHOBQJBNB-QGZVFWFLSA-N

Data: 2 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50316922   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM50316922 ((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CC[C@H](C2)N(C)C)cc1 |r| Show InChI InChI=1S/C21H26N4O/c1-23(2)17-12-13-24(15-17)21-22-19-6-4-5-7-20(19)25(21)14-16-8-10-18(26-3)11-9-16/h4-11,17H,12-15H2,1-3H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting				Bioorg Med Chem Lett 20: 2916-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.027 BindingDB Entry DOI: 10.7270/Q20865G0
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50316922 ((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CC[C@H](C2)N(C)C)cc1 |r| Show InChI InChI=1S/C21H26N4O/c1-23(2)17-12-13-24(15-17)21-22-19-6-4-5-7-20(19)25(21)14-16-8-10-18(26-3)11-9-16/h4-11,17H,12-15H2,1-3H3/t17-/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Displacement of [3H]N-methyl scopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation counting				Bioorg Med Chem Lett 20: 2916-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.027 BindingDB Entry DOI: 10.7270/Q20865G0
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50316922 ((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CC[C@H](C2)N(C)C)cc1 |r| Show InChI InChI=1S/C21H26N4O/c1-23(2)17-12-13-24(15-17)21-22-19-6-4-5-7-20(19)25(21)14-16-8-10-18(26-3)11-9-16/h4-11,17H,12-15H2,1-3H3/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem Lett 20: 2916-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.027 BindingDB Entry DOI: 10.7270/Q20865G0
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50316922 ((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CC[C@H](C2)N(C)C)cc1 |r| Show InChI InChI=1S/C21H26N4O/c1-23(2)17-12-13-24(15-17)21-22-19-6-4-5-7-20(19)25(21)14-16-8-10-18(26-3)11-9-16/h4-11,17H,12-15H2,1-3H3/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	492	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Inhibition of human ERG channel by electrophysiology assay				Bioorg Med Chem Lett 20: 2916-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.027 BindingDB Entry DOI: 10.7270/Q20865G0
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50316922 ((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CC[C@H](C2)N(C)C)cc1 |r| Show InChI InChI=1S/C21H26N4O/c1-23(2)17-12-13-24(15-17)21-22-19-6-4-5-7-20(19)25(21)14-16-8-10-18(26-3)11-9-16/h4-11,17H,12-15H2,1-3H3/t17-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Inhibition of CYP2D6				Bioorg Med Chem Lett 20: 2916-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.027 BindingDB Entry DOI: 10.7270/Q20865G0
					More data for this Ligand-Target Pair