BDBM50319352 3-[1-(1-adamantyl)-1H-tetrazol-5-yl]-1-phenylpropan-1-one::CHEMBL1083421

SMILES: O=C(CCc1cnnn1[C@@]12CC3CC(CC(C3)C1)C2)c1ccccc1

InChI Key: InChIKey=IAOPKSJTEMBPOC-BRXFORFLSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50319352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50319352 (3-[1-(1-adamantyl)-1H-tetrazol-5-yl]-1-phenylpropa...) Show SMILES O=C(CCc1cnnn1[C@@]12CC3CC(CC(C3)C1)C2)c1ccccc1 |r,TLB:8:9:12:16.14.15,THB:14:13:10:16.15.17,14:15:12.13.18:10,17:9:12:16.14.15,17:15:12:9.18.10| Show InChI InChI=1S/C21H25N3O/c25-20(18-4-2-1-3-5-18)7-6-19-14-22-23-24(19)21-11-15-8-16(12-21)10-17(9-15)13-21/h1-5,14-17H,6-13H2/t15?,16?,17?,21-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Edinburgh Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells by scintillation proximity assay				Bioorg Med Chem Lett 20: 3265-71 (2010) Article DOI: 10.1016/j.bmcl.2010.04.055 BindingDB Entry DOI: 10.7270/Q2ZS2WPQ
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