BDBM50321903 (Z)-5-((6-(3-(4-methoxyphenyl)ureido)-2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-2-carboxylic acid::CHEMBL1173244

SMILES: COc1ccc(NC(=O)Nc2ccc3\C(=C\c4ccc([nH]4)C(O)=O)C(=O)Nc3c2)cc1

InChI Key: InChIKey=RMPQFEZMASYAHZ-YVLHZVERSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50321903   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50321903 ((Z)-5-((6-(3-(4-methoxyphenyl)ureido)-2-oxoindolin...) Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4ccc([nH]4)C(O)=O)C(=O)Nc3c2)cc1 Show InChI InChI=1S/C22H18N4O5/c1-31-15-6-2-12(3-7-15)24-22(30)25-14-4-8-16-17(20(27)26-19(16)11-14)10-13-5-9-18(23-13)21(28)29/h2-11,23H,1H3,(H,26,27)(H,28,29)(H2,24,25,30)/b17-10-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University Curated by ChEMBL					Assay Description Inhibition of VEGFR3				Bioorg Med Chem 18: 4674-86 (2011) Article DOI: 10.1016/j.bmc.2010.05.021 BindingDB Entry DOI: 10.7270/Q2QF8TVS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50321903 ((Z)-5-((6-(3-(4-methoxyphenyl)ureido)-2-oxoindolin...) Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4ccc([nH]4)C(O)=O)C(=O)Nc3c2)cc1 Show InChI InChI=1S/C22H18N4O5/c1-31-15-6-2-12(3-7-15)24-22(30)25-14-4-8-16-17(20(27)26-19(16)11-14)10-13-5-9-18(23-13)21(28)29/h2-11,23H,1H3,(H,26,27)(H,28,29)(H2,24,25,30)/b17-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem 18: 4674-86 (2011) Article DOI: 10.1016/j.bmc.2010.05.021 BindingDB Entry DOI: 10.7270/Q2QF8TVS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50321903 ((Z)-5-((6-(3-(4-methoxyphenyl)ureido)-2-oxoindolin...) Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4ccc([nH]4)C(O)=O)C(=O)Nc3c2)cc1 Show InChI InChI=1S/C22H18N4O5/c1-31-15-6-2-12(3-7-15)24-22(30)25-14-4-8-16-17(20(27)26-19(16)11-14)10-13-5-9-18(23-13)21(28)29/h2-11,23H,1H3,(H,26,27)(H,28,29)(H2,24,25,30)/b17-10-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University Curated by ChEMBL					Assay Description Inhibition of FLT3				Bioorg Med Chem 18: 4674-86 (2011) Article DOI: 10.1016/j.bmc.2010.05.021 BindingDB Entry DOI: 10.7270/Q2QF8TVS
					More data for this Ligand-Target Pair