BindingDB logo
myBDB logout

null

SMILES: Fc1cc(cc(c1)C(=O)Nc1cccc(n1)C(F)(F)F)C#N

InChI Key: InChIKey=CCTMTFUWMFQSOX-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50323303   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50323303
PNG
(3-cyano-5-fluoro-N-(6-(trifluoromethyl)pyridin-2-y...)
Show SMILES Fc1cc(cc(c1)C(=O)Nc1cccc(n1)C(F)(F)F)C#N
Show InChI InChI=1S/C14H7F4N3O/c15-10-5-8(7-19)4-9(6-10)13(22)21-12-3-1-2-11(20-12)14(16,17)18/h1-6H,(H,20,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 20: 4390-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.064
BindingDB Entry DOI: 10.7270/Q2V9888D
More data for this
Ligand-Target Pair