BDBM50325017 (R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(4-(3-phenylisoxazol-5-yl)phenyl)imidazolidine-2,4-dione::CHEMBL1223223

SMILES: COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccc(cc3)-c3cc(no3)-c3ccccc3)C(=O)c2c1

InChI Key: InChIKey=NVWXOYMJYWFJGW-NDEPHWFRSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325017   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50325017 ((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...) Show SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccc(cc3)-c3cc(no3)-c3ccccc3)C(=O)c2c1 |r| Show InChI InChI=1S/C28H22N4O5/c1-36-21-12-9-19-15-32(25(33)22(19)13-21)16-28(26(34)29-27(35)30-28)20-10-7-18(8-11-20)24-14-23(31-37-24)17-5-3-2-4-6-17/h2-14H,15-16H2,1H3,(H2,29,30,34,35)/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavage				Bioorg Med Chem Lett 20: 5286-9 (2010) Article DOI: 10.1016/j.bmcl.2010.06.134 BindingDB Entry DOI: 10.7270/Q26W9B8K
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