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BDBM50325478 1-phenyl-8-(1-(pyridin-4-ylmethyl)piperidine-4-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL1222486

SMILES: O=C(C1CCN(Cc2ccncc2)CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key: InChIKey=HTGDDNXHBUCALC-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325478   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HRH3


(GUINEA PIG)		BDBM50325478
PNG
(1-phenyl-8-(1-(pyridin-4-ylmethyl)piperidine-4-car...)
Show SMILES O=C(C1CCN(Cc2ccncc2)CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C25H31N5O2/c31-23(21-8-14-28(15-9-21)18-20-6-12-26-13-7-20)29-16-10-25(11-17-29)24(32)27-19-30(25)22-4-2-1-3-5-22/h1-7,12-13,21H,8-11,14-19H2,(H,27,32)
UniProtKB/SwissProt

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Article
PubMed
 20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain

Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair