BDBM50326164 (E)-8-{2-[3-(2-Carboxyvinyl)phenyl]thiazol-4-yl}dibenzo[b,d]furan-4-carboxylic acid::CHEMBL1241469

SMILES: OC(=O)\C=C\c1cccc(c1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O

InChI Key: InChIKey=IPDAFAFOOCIFDG-JXMROGBWSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50326164   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50326164 ((E)-8-{2-[3-(2-Carboxyvinyl)phenyl]thiazol-4-yl}di...) Show SMILES OC(=O)\C=C\c1cccc(c1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O Show InChI InChI=1S/C25H15NO5S/c27-22(28)10-7-14-3-1-4-16(11-14)24-26-20(13-32-24)15-8-9-21-19(12-15)17-5-2-6-18(25(29)30)23(17)31-21/h1-13H,(H,27,28)(H,29,30)/b10-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	551	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant PTP1B after 30 mins by spectrophotometry				Eur J Med Chem 45: 3709-18 (2010) Article DOI: 10.1016/j.ejmech.2010.05.020 BindingDB Entry DOI: 10.7270/Q24Q7V6S
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR) (Homo sapiens (Human))	BDBM50326164 ((E)-8-{2-[3-(2-Carboxyvinyl)phenyl]thiazol-4-yl}di...) Show SMILES OC(=O)\C=C\c1cccc(c1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O Show InChI InChI=1S/C25H15NO5S/c27-22(28)10-7-14-3-1-4-16(11-14)24-26-20(13-32-24)15-8-9-21-19(12-15)17-5-2-6-18(25(29)30)23(17)31-21/h1-13H,(H,27,28)(H,29,30)/b10-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant LAR after 30 mins by spectrophotometry				Eur J Med Chem 45: 3709-18 (2010) Article DOI: 10.1016/j.ejmech.2010.05.020 BindingDB Entry DOI: 10.7270/Q24Q7V6S
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human))	BDBM50326164 ((E)-8-{2-[3-(2-Carboxyvinyl)phenyl]thiazol-4-yl}di...) Show SMILES OC(=O)\C=C\c1cccc(c1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O Show InChI InChI=1S/C25H15NO5S/c27-22(28)10-7-14-3-1-4-16(11-14)24-26-20(13-32-24)15-8-9-21-19(12-15)17-5-2-6-18(25(29)30)23(17)31-21/h1-13H,(H,27,28)(H,29,30)/b10-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
Glenmark Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant TCPTP after 30 mins by spectrophotometry				Eur J Med Chem 45: 3709-18 (2010) Article DOI: 10.1016/j.ejmech.2010.05.020 BindingDB Entry DOI: 10.7270/Q24Q7V6S
					More data for this Ligand-Target Pair