BDBM50327453 1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonothioyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid::CHEMBL1257723

SMILES: CC(=NNC(=S)N1CCCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O

InChI Key: InChIKey=MTMWEAXUWOGWBN-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327453   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327453 (1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...) Show SMILES CC(=NNC(=S)N1CCCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:2.2| Show InChI InChI=1S/C25H27N5O3S/c1-14-7-9-20(12-15(14)2)30-23(31)22(17(4)28-30)16(3)26-27-25(34)29-11-5-6-18-13-19(24(32)33)8-10-21(18)29/h7-10,12-13,28H,5-6,11H2,1-4H3,(H,27,34)(H,32,33)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	64	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair