BDBM50327678 11H-dibenzo[b,e]azepine-10-carboxylic acid butyl ester hydrochloride::CHEMBL1084638::CHEMBL1258323

SMILES: CCCCOC(=O)c1cccc2C=Nc3ccccc3Cc12

InChI Key: InChIKey=WRWJPMLGCZXXPT-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50327678   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50327678 (11H-dibenzo[b,e]azepine-10-carboxylic acid butyl e...) Show SMILES CCCCOC(=O)c1cccc2C=Nc3ccccc3Cc12 |c:12| Show InChI InChI=1S/C19H19NO2/c1-2-3-11-22-19(21)16-9-6-8-15-13-20-18-10-5-4-7-14(18)12-17(15)16/h4-10,13H,2-3,11-12H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.51	n/a	n/a	n/a	n/a
Ferrara University Curated by ChEMBL					Assay Description Activation of human TRPA1 channel				J Med Chem 53: 5085-107 (2010) Article DOI: 10.1021/jm100062h BindingDB Entry DOI: 10.7270/Q2416Z02
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50327678 (11H-dibenzo[b,e]azepine-10-carboxylic acid butyl e...) Show SMILES CCCCOC(=O)c1cccc2C=Nc3ccccc3Cc12 |c:12| Show InChI InChI=1S/C19H19NO2/c1-2-3-11-22-19(21)16-9-6-8-15-13-20-18-10-5-4-7-14(18)12-17(15)16/h4-10,13H,2-3,11-12H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assay				J Med Chem 53: 7011-20 (2010) Article DOI: 10.1021/jm100477n BindingDB Entry DOI: 10.7270/Q2474B2T
					More data for this Ligand-Target Pair