BDBM50328066 6-(2,6-dimethylmorpholino)-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1258468

SMILES: COc1cccc(Nc2nc(nc3n(C)ncc23)N2CC(C)OC(C)C2)c1

InChI Key: InChIKey=CESZXTGKEPVZCH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328066   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50328066 (6-(2,6-dimethylmorpholino)-N-(3-methoxyphenyl)-1-m...) Show SMILES COc1cccc(Nc2nc(nc3n(C)ncc23)N2CC(C)OC(C)C2)c1 Show InChI InChI=1S/C19H24N6O2/c1-12-10-25(11-13(2)27-12)19-22-17(16-9-20-24(3)18(16)23-19)21-14-6-5-7-15(8-14)26-4/h5-9,12-13H,10-11H2,1-4H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				Bioorg Med Chem Lett 20: 6048-51 (2010) Article DOI: 10.1016/j.bmcl.2010.08.067 BindingDB Entry DOI: 10.7270/Q2ST7Q28
					More data for this Ligand-Target Pair