BDBM50328508 2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-2-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile::CHEMBL1259007

SMILES: COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccc2ccccc2c1

InChI Key: InChIKey=BDZVZSQHUIXJHW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50328508 (2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-2-yl)-5...) Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccc2ccccc2c1 |c:16| Show InChI InChI=1S/C27H22N2O3/c1-31-21-10-8-17(9-11-21)25-22(15-28)27(29)32-24-14-20(13-23(30)26(24)25)19-7-6-16-4-2-3-5-18(16)12-19/h2-12,20,22,25,29H,13-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay				J Med Chem 53: 7180-91 (2010) Article DOI: 10.1021/jm1009154 BindingDB Entry DOI: 10.7270/Q2VM4CGX
					More data for this Ligand-Target Pair