BDBM50329296 (R)-3-(Benzyl-tert-butoxycarbonyl-amino)-pyrrolidine-1-carboxylic acid adamantan-2-yl ester::CHEMBL1270603

SMILES: CC(C)(C)OC(=O)N(Cc1ccccc1)[C@@H]1CCN(C1)C(=O)OC1C2CC3CC(C2)CC1C3

InChI Key: InChIKey=KGWQMOSTUQELOI-ASTQULEJSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329296   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50329296 ((R)-3-(Benzyl-tert-butoxycarbonyl-amino)-pyrrolidi...) Show SMILES CC(C)(C)OC(=O)N(Cc1ccccc1)[C@@H]1CCN(C1)C(=O)OC1C2CC3CC(C2)CC1C3 |r,wU:15.15,TLB:29:28:32:25.24.23,29:24:27.28.30:32,THB:23:24:27:30.31.32,23:31:27:25.29.24,22:23:27.28.30:32,(22.47,-24.3,;20.93,-24.28,;20.18,-22.93,;21.69,-22.94,;20.14,-25.6,;18.6,-25.58,;17.85,-24.23,;17.81,-26.9,;18.56,-28.24,;20.1,-28.27,;20.84,-29.61,;22.38,-29.64,;23.17,-28.32,;22.42,-26.97,;20.88,-26.95,;16.27,-26.87,;15.38,-25.61,;13.91,-26.06,;13.88,-27.61,;15.34,-28.1,;12.54,-28.37,;12.53,-29.91,;11.22,-27.58,;9.88,-28.34,;9.86,-29.87,;8.47,-30.22,;7.14,-29.73,;5.94,-31,;7.45,-30.58,;8.85,-31.15,;7.44,-29,;8.48,-27.76,;7.13,-28.24,)| Show InChI InChI=1S/C27H38N2O4/c1-27(2,3)33-26(31)29(16-18-7-5-4-6-8-18)23-9-10-28(17-23)25(30)32-24-21-12-19-11-20(14-21)15-22(24)13-19/h4-8,19-24H,9-17H2,1-3H3/t19?,20?,21?,22?,23-,24?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader				Bioorg Med Chem Lett 20: 6725-9 (2010) Article DOI: 10.1016/j.bmcl.2010.08.142 BindingDB Entry DOI: 10.7270/Q2X92BJ5
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50329296 ((R)-3-(Benzyl-tert-butoxycarbonyl-amino)-pyrrolidi...) Show SMILES CC(C)(C)OC(=O)N(Cc1ccccc1)[C@@H]1CCN(C1)C(=O)OC1C2CC3CC(C2)CC1C3 |r,wU:15.15,TLB:29:28:32:25.24.23,29:24:27.28.30:32,THB:23:24:27:30.31.32,23:31:27:25.29.24,22:23:27.28.30:32,(22.47,-24.3,;20.93,-24.28,;20.18,-22.93,;21.69,-22.94,;20.14,-25.6,;18.6,-25.58,;17.85,-24.23,;17.81,-26.9,;18.56,-28.24,;20.1,-28.27,;20.84,-29.61,;22.38,-29.64,;23.17,-28.32,;22.42,-26.97,;20.88,-26.95,;16.27,-26.87,;15.38,-25.61,;13.91,-26.06,;13.88,-27.61,;15.34,-28.1,;12.54,-28.37,;12.53,-29.91,;11.22,-27.58,;9.88,-28.34,;9.86,-29.87,;8.47,-30.22,;7.14,-29.73,;5.94,-31,;7.45,-30.58,;8.85,-31.15,;7.44,-29,;8.48,-27.76,;7.13,-28.24,)| Show InChI InChI=1S/C27H38N2O4/c1-27(2,3)33-26(31)29(16-18-7-5-4-6-8-18)23-9-10-28(17-23)25(30)32-24-21-12-19-11-20(14-21)15-22(24)13-19/h4-8,19-24H,9-17H2,1-3H3/t19?,20?,21?,22?,23-,24?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	15.3	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader				Bioorg Med Chem Lett 20: 6725-9 (2010) Article DOI: 10.1016/j.bmcl.2010.08.142 BindingDB Entry DOI: 10.7270/Q2X92BJ5
					More data for this Ligand-Target Pair