BDBM50330263 4-(3-Isopropyl-5-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-(1-methyl-piperidin-4-yl)-amine::CHEMBL1271510

SMILES: CC(C)c1n[nH]c(C)c1-c1ccnc(NC2CCN(C)CC2)n1

InChI Key: InChIKey=XVSGVXXZKSGHBM-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330263   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM50330263 (4-(3-Isopropyl-5-methyl-1H-pyrazol-4-yl)-pyrimidin...) Show SMILES CC(C)c1n[nH]c(C)c1-c1ccnc(NC2CCN(C)CC2)n1 Show InChI InChI=1S/C17H26N6/c1-11(2)16-15(12(3)21-22-16)14-5-8-18-17(20-14)19-13-6-9-23(4)10-7-13/h5,8,11,13H,6-7,9-10H2,1-4H3,(H,21,22)(H,18,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human CDK6/cyclin D3 after 2 hrs by TR-FRET assay				J Med Chem 53: 7938-57 (2010) Article DOI: 10.1021/jm100571n BindingDB Entry DOI: 10.7270/Q2T72HQV
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM50330263 (4-(3-Isopropyl-5-methyl-1H-pyrazol-4-yl)-pyrimidin...) Show SMILES CC(C)c1n[nH]c(C)c1-c1ccnc(NC2CCN(C)CC2)n1 Show InChI InChI=1S/C17H26N6/c1-11(2)16-15(12(3)21-22-16)14-5-8-18-17(20-14)19-13-6-9-23(4)10-7-13/h5,8,11,13H,6-7,9-10H2,1-4H3,(H,21,22)(H,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assay				J Med Chem 53: 7938-57 (2010) Article DOI: 10.1021/jm100571n BindingDB Entry DOI: 10.7270/Q2T72HQV
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM50330263 (4-(3-Isopropyl-5-methyl-1H-pyrazol-4-yl)-pyrimidin...) Show SMILES CC(C)c1n[nH]c(C)c1-c1ccnc(NC2CCN(C)CC2)n1 Show InChI InChI=1S/C17H26N6/c1-11(2)16-15(12(3)21-22-16)14-5-8-18-17(20-14)19-13-6-9-23(4)10-7-13/h5,8,11,13H,6-7,9-10H2,1-4H3,(H,21,22)(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assay				J Med Chem 53: 7938-57 (2010) Article DOI: 10.1021/jm100571n BindingDB Entry DOI: 10.7270/Q2T72HQV
					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50330263 (4-(3-Isopropyl-5-methyl-1H-pyrazol-4-yl)-pyrimidin...) Show SMILES CC(C)c1n[nH]c(C)c1-c1ccnc(NC2CCN(C)CC2)n1 Show InChI InChI=1S/C17H26N6/c1-11(2)16-15(12(3)21-22-16)14-5-8-18-17(20-14)19-13-6-9-23(4)10-7-13/h5,8,11,13H,6-7,9-10H2,1-4H3,(H,21,22)(H,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assay				J Med Chem 53: 7938-57 (2010) Article DOI: 10.1021/jm100571n BindingDB Entry DOI: 10.7270/Q2T72HQV
					More data for this Ligand-Target Pair