BDBM50330944 CHEMBL1278044::N-(3,5-Dimethylphenyl)-6-(4-cyanophenyl)-pyrazine-2-carboxamide

SMILES: Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(cc2)C#N)c1

InChI Key: InChIKey=UFTSEYQJZURHKC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330944   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM50330944 (CHEMBL1278044 | N-(3,5-Dimethylphenyl)-6-(4-cyanop...) Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(cc2)C#N)c1 Show InChI InChI=1S/C20H16N4O/c1-13-7-14(2)9-17(8-13)23-20(25)19-12-22-11-18(24-19)16-5-3-15(10-21)4-6-16/h3-9,11-12H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant NaV1.2 by electrophysiology				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8 (Rattus norvegicus (Rat))	BDBM50330944 (CHEMBL1278044 | N-(3,5-Dimethylphenyl)-6-(4-cyanop...) Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(cc2)C#N)c1 Show InChI InChI=1S/C20H16N4O/c1-13-7-14(2)9-17(8-13)23-20(25)19-12-22-11-18(24-19)16-5-3-15(10-21)4-6-16/h3-9,11-12H,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM50330944 (CHEMBL1278044 | N-(3,5-Dimethylphenyl)-6-(4-cyanop...) Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(cc2)C#N)c1 Show InChI InChI=1S/C20H16N4O/c1-13-7-14(2)9-17(8-13)23-20(25)19-12-22-11-18(24-19)16-5-3-15(10-21)4-6-16/h3-9,11-12H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assay				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Sodium channel protein type X alpha subunit (Mus musculus)	BDBM50330944 (CHEMBL1278044 | N-(3,5-Dimethylphenyl)-6-(4-cyanop...) Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(n2)-c2ccc(cc2)C#N)c1 Show InChI InChI=1S/C20H16N4O/c1-13-7-14(2)9-17(8-13)23-20(25)19-12-22-11-18(24-19)16-5-3-15(10-21)4-6-16/h3-9,11-12H,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assay				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair