BDBM50331358 CHEMBL1289178::rac-1-(3-chloro-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)benzyl)cyclopropanecarbonitrile

SMILES: CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(CC2(CC2)C#N)cc1Cl)C(F)(F)F

InChI Key: InChIKey=GXMKJDRDNOREPB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50331358   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50331358 (CHEMBL1289178 | rac-1-(3-chloro-4-(4-(1,1,1-triflu...) Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(CC2(CC2)C#N)cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H17ClF3NO3S/c1-18(26,20(22,23)24)14-3-5-15(6-4-14)29(27,28)17-7-2-13(10-16(17)21)11-19(12-25)8-9-19/h2-7,10,26H,8-9,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay				Bioorg Med Chem Lett 20: 7071-5 (2010) Article DOI: 10.1016/j.bmcl.2010.09.097 BindingDB Entry DOI: 10.7270/Q21G0MHX
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50331358 (CHEMBL1289178 | rac-1-(3-chloro-4-(4-(1,1,1-triflu...) Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(CC2(CC2)C#N)cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H17ClF3NO3S/c1-18(26,20(22,23)24)14-3-5-15(6-4-14)29(27,28)17-7-2-13(10-16(17)21)11-19(12-25)8-9-19/h2-7,10,26H,8-9,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 by scintillation proximity assay				Bioorg Med Chem Lett 20: 7071-5 (2010) Article DOI: 10.1016/j.bmcl.2010.09.097 BindingDB Entry DOI: 10.7270/Q21G0MHX
					More data for this Ligand-Target Pair