BDBM50331417 CHEMBL1290506::N-{3-[(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-(3-trifluorome thyl-phenyl)-amino]-propyl}-4-fluoro-benzamide

SMILES: Fc1ccc(cc1)C(=O)NCCCN(C1=NS(=O)(=O)c2ccccc12)c1cccc(c1)C(F)(F)F

InChI Key: InChIKey=GUTOHOIAERGRIR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50331417 (CHEMBL1290506 | N-{3-[(1,1-Dioxo-1H-1lambda*6*-ben...) Show SMILES Fc1ccc(cc1)C(=O)NCCCN(C1=NS(=O)(=O)c2ccccc12)c1cccc(c1)C(F)(F)F |t:15| Show InChI InChI=1S/C24H19F4N3O3S/c25-18-11-9-16(10-12-18)23(32)29-13-4-14-31(19-6-3-5-17(15-19)24(26,27)28)22-20-7-1-2-8-21(20)35(33,34)30-22/h1-3,5-12,15H,4,13-14H2,(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay				Bioorg Med Chem Lett 20: 6983-8 (2010) Article DOI: 10.1016/j.bmcl.2010.09.132 BindingDB Entry DOI: 10.7270/Q2N58MMS
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