BDBM50331474 CHEMBL1290618::Pyrrole-1-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

SMILES: CC(C)(CNC(=O)n1cccc1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1

InChI Key: InChIKey=KSZRMQOUHDNLBY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50331474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated potassium channel subunit Kv1.5 (Homo sapiens (Human))	BDBM50331474 (CHEMBL1290618 | Pyrrole-1-carboxylic acid{3-[(6-fl...) Show SMILES CC(C)(CNC(=O)n1cccc1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H23FN4O3S/c1-23(2,15-25-22(29)27-12-6-7-13-27)16-28(18-8-4-3-5-9-18)21-19-11-10-17(24)14-20(19)32(30,31)26-21/h3-14H,15-16H2,1-2H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells				Bioorg Med Chem Lett 20: 6989-92 (2010) Article DOI: 10.1016/j.bmcl.2010.09.131 BindingDB Entry DOI: 10.7270/Q2HD7VW2
					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50331474 (CHEMBL1290618 | Pyrrole-1-carboxylic acid{3-[(6-fl...) Show SMILES CC(C)(CNC(=O)n1cccc1)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:15| Show InChI InChI=1S/C23H23FN4O3S/c1-23(2,15-25-22(29)27-12-6-7-13-27)16-28(18-8-4-3-5-9-18)21-19-11-10-17(24)14-20(19)32(30,31)26-21/h3-14H,15-16H2,1-2H3,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human Kv1.3 ion channel expressed in CGE22 cells				Bioorg Med Chem Lett 20: 6989-92 (2010) Article DOI: 10.1016/j.bmcl.2010.09.131 BindingDB Entry DOI: 10.7270/Q2HD7VW2
					More data for this Ligand-Target Pair