BDBM50331901 CHEMBL1289341::E-5-Bromo-3-[[4-(methylsulfonyl)phenyl]methylene]-indolin-2-one
SMILES: CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(Br)cc23)cc1
InChI Key: InChIKey=PJOBZMKBVWXAHD-RIYZIHGNSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 (Oryctolagus cuniculus) | BDBM50331901 (CHEMBL1289341 | E-5-Bromo-3-[[4-(methylsulfonyl)ph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c... | Bioorg Med Chem Lett 20: 7349-53 (2010) Article DOI: 10.1016/j.bmcl.2010.10.056 BindingDB Entry DOI: 10.7270/Q21836QQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclooxygenase-1 (Oryctolagus cuniculus) | BDBM50331901 (CHEMBL1289341 | E-5-Bromo-3-[[4-(methylsulfonyl)ph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of COX-1 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs by HPLC in presence of c... | Bioorg Med Chem Lett 20: 7349-53 (2010) Article DOI: 10.1016/j.bmcl.2010.10.056 BindingDB Entry DOI: 10.7270/Q21836QQ | |||||||||||
More data for this Ligand-Target Pair |