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SMILES: Fc1ccc(N2CCN(CC2)C(=O)COCc2ccccc2)c(F)c1

InChI Key: InChIKey=LISIBTYUESGZGJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331981   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50331981
PNG
(2-(benzyloxy)-1-(4-(2,4-difluorophenyl)piperazin-1...)
Show SMILES Fc1ccc(N2CCN(CC2)C(=O)COCc2ccccc2)c(F)c1
Show InChI InChI=1S/C19H20F2N2O2/c20-16-6-7-18(17(21)12-16)22-8-10-23(11-9-22)19(24)14-25-13-15-4-2-1-3-5-15/h1-7,12H,8-11,13-14H2
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Article
PubMed
n/an/an/an/a 300n/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay

Bioorg Med Chem Lett 20: 7381-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.036
BindingDB Entry DOI: 10.7270/Q27S7P13
More data for this
Ligand-Target Pair