BDBM50332090 2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-yl)acetamide::CHEMBL1288159::US9796706, Compound 86

SMILES: O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1

InChI Key: InChIKey=ALHGQWSWTWVNNB-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50332090   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50332090 (2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...) Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50332090 (2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...) Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50332090 (2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...) Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50332090 (2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...) Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	5.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
IMAGO PHARMACEUTICALS, INC. US Patent					Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...				US Patent US9796706 (2017) BindingDB Entry DOI: 10.7270/Q24T6MHK
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50332090 (2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...) Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50332090 (2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...) Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	5.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
IMAGO PHARMACEUTICALS, INC. US Patent					Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...				US Patent US9796706 (2017) BindingDB Entry DOI: 10.7270/Q24T6MHK
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50332090 (2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...) Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	5.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
IMAGO PHARMACEUTICALS, INC. US Patent					Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...				US Patent US9796706 (2017) BindingDB Entry DOI: 10.7270/Q24T6MHK
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50332090 (2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-...) Show SMILES O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 Show InChI InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair