BDBM50334683 ((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamido)-1-(5-fluoropyridin-2-yl)cyclohexyl)methyl carbamate::CHEMBL1642587

SMILES: C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](COC(N)=O)(CC1)c1ccc(F)cn1)C(F)(F)F

InChI Key: InChIKey=DLFDULGVWFEIQL-OPXMRZJTSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50334683   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50334683 (((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...) Show SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](COC(N)=O)(CC1)c1ccc(F)cn1)C(F)(F)F |r,wU:1.0,15.16,wD:1.1,18.28,(-7.82,-30.88,;-6.49,-30.1,;-7.98,-29.71,;-5.15,-30.87,;-3.81,-30.09,;-2.48,-30.86,;-2.48,-32.4,;-3.8,-33.18,;-5.14,-32.42,;-1.14,-33.17,;-1.14,-34.71,;.19,-32.39,;.18,-30.85,;.95,-29.52,;-.59,-29.52,;1.53,-33.16,;2.86,-32.38,;4.19,-33.16,;4.19,-34.7,;5.66,-34.25,;6.79,-35.3,;8.26,-34.84,;9.39,-35.89,;8.6,-33.34,;2.86,-35.46,;1.53,-34.7,;4.94,-36.03,;6.47,-36.04,;7.23,-37.36,;6.45,-38.69,;7.22,-40.03,;4.92,-38.68,;4.16,-37.35,;-6.49,-28.56,;-5.16,-27.78,;-7.83,-27.8,;-6.9,-27.07,)| Show InChI InChI=1S/C26H29F4N3O4/c1-24(36,26(28,29)30)17-4-2-16(3-5-17)22(34)33(19-7-8-19)20-10-12-25(13-11-20,15-37-23(31)35)21-9-6-18(27)14-32-21/h2-6,9,14,19-20,36H,7-8,10-13,15H2,1H3,(H2,31,35)/t20-,24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human recombinant full length 11beta-HSD1 expressed in human adipocytes assessed as inhibition of conversion of [3H]cortisone to [3H]co...				Bioorg Med Chem Lett 21: 405-10 (2010) Article DOI: 10.1016/j.bmcl.2010.10.129 BindingDB Entry DOI: 10.7270/Q2K937SB
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50334683 (((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...) Show SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](COC(N)=O)(CC1)c1ccc(F)cn1)C(F)(F)F |r,wU:1.0,15.16,wD:1.1,18.28,(-7.82,-30.88,;-6.49,-30.1,;-7.98,-29.71,;-5.15,-30.87,;-3.81,-30.09,;-2.48,-30.86,;-2.48,-32.4,;-3.8,-33.18,;-5.14,-32.42,;-1.14,-33.17,;-1.14,-34.71,;.19,-32.39,;.18,-30.85,;.95,-29.52,;-.59,-29.52,;1.53,-33.16,;2.86,-32.38,;4.19,-33.16,;4.19,-34.7,;5.66,-34.25,;6.79,-35.3,;8.26,-34.84,;9.39,-35.89,;8.6,-33.34,;2.86,-35.46,;1.53,-34.7,;4.94,-36.03,;6.47,-36.04,;7.23,-37.36,;6.45,-38.69,;7.22,-40.03,;4.92,-38.68,;4.16,-37.35,;-6.49,-28.56,;-5.16,-27.78,;-7.83,-27.8,;-6.9,-27.07,)| Show InChI InChI=1S/C26H29F4N3O4/c1-24(36,26(28,29)30)17-4-2-16(3-5-17)22(34)33(19-7-8-19)20-10-12-25(13-11-20,15-37-23(31)35)21-9-6-18(27)14-32-21/h2-6,9,14,19-20,36H,7-8,10-13,15H2,1H3,(H2,31,35)/t20-,24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human recombinant full length 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of conversion of [3H]cortisone to [3H]cortis...				Bioorg Med Chem Lett 21: 405-10 (2010) Article DOI: 10.1016/j.bmcl.2010.10.129 BindingDB Entry DOI: 10.7270/Q2K937SB
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50334683 (((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...) Show SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](COC(N)=O)(CC1)c1ccc(F)cn1)C(F)(F)F |r,wU:1.0,15.16,wD:1.1,18.28,(-7.82,-30.88,;-6.49,-30.1,;-7.98,-29.71,;-5.15,-30.87,;-3.81,-30.09,;-2.48,-30.86,;-2.48,-32.4,;-3.8,-33.18,;-5.14,-32.42,;-1.14,-33.17,;-1.14,-34.71,;.19,-32.39,;.18,-30.85,;.95,-29.52,;-.59,-29.52,;1.53,-33.16,;2.86,-32.38,;4.19,-33.16,;4.19,-34.7,;5.66,-34.25,;6.79,-35.3,;8.26,-34.84,;9.39,-35.89,;8.6,-33.34,;2.86,-35.46,;1.53,-34.7,;4.94,-36.03,;6.47,-36.04,;7.23,-37.36,;6.45,-38.69,;7.22,-40.03,;4.92,-38.68,;4.16,-37.35,;-6.49,-28.56,;-5.16,-27.78,;-7.83,-27.8,;-6.9,-27.07,)| Show InChI InChI=1S/C26H29F4N3O4/c1-24(36,26(28,29)30)17-4-2-16(3-5-17)22(34)33(19-7-8-19)20-10-12-25(13-11-20,15-37-23(31)35)21-9-6-18(27)14-32-21/h2-6,9,14,19-20,36H,7-8,10-13,15H2,1H3,(H2,31,35)/t20-,24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human recombinant full length 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of conversion of [3H]cortisone to [3H]cortis...				Bioorg Med Chem Lett 21: 405-10 (2010) Article DOI: 10.1016/j.bmcl.2010.10.129 BindingDB Entry DOI: 10.7270/Q2K937SB
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50334683 (((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...) Show SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](COC(N)=O)(CC1)c1ccc(F)cn1)C(F)(F)F |r,wU:1.0,15.16,wD:1.1,18.28,(-7.82,-30.88,;-6.49,-30.1,;-7.98,-29.71,;-5.15,-30.87,;-3.81,-30.09,;-2.48,-30.86,;-2.48,-32.4,;-3.8,-33.18,;-5.14,-32.42,;-1.14,-33.17,;-1.14,-34.71,;.19,-32.39,;.18,-30.85,;.95,-29.52,;-.59,-29.52,;1.53,-33.16,;2.86,-32.38,;4.19,-33.16,;4.19,-34.7,;5.66,-34.25,;6.79,-35.3,;8.26,-34.84,;9.39,-35.89,;8.6,-33.34,;2.86,-35.46,;1.53,-34.7,;4.94,-36.03,;6.47,-36.04,;7.23,-37.36,;6.45,-38.69,;7.22,-40.03,;4.92,-38.68,;4.16,-37.35,;-6.49,-28.56,;-5.16,-27.78,;-7.83,-27.8,;-6.9,-27.07,)| Show InChI InChI=1S/C26H29F4N3O4/c1-24(36,26(28,29)30)17-4-2-16(3-5-17)22(34)33(19-7-8-19)20-10-12-25(13-11-20,15-37-23(31)35)21-9-6-18(27)14-32-21/h2-6,9,14,19-20,36H,7-8,10-13,15H2,1H3,(H2,31,35)/t20-,24-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human full length 11beta-HSD1 assessed as inhibition of conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay				Bioorg Med Chem Lett 21: 405-10 (2010) Article DOI: 10.1016/j.bmcl.2010.10.129 BindingDB Entry DOI: 10.7270/Q2K937SB
					More data for this Ligand-Target Pair