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SMILES: Cc1cc(C(=O)Nc2ccn[nH]2)c2nc(C)nc(N)c2c1

InChI Key: InChIKey=ICOTWOFYQBMZHO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50336404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50336404 (4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...) Show SMILES Cc1cc(C(=O)Nc2ccn[nH]2)c2nc(C)nc(N)c2c1 Show InChI InChI=1S/C14H14N6O/c1-7-5-9-12(17-8(2)18-13(9)15)10(6-7)14(21)19-11-3-4-16-20-11/h3-6H,1-2H3,(H2,15,17,18)(H2,16,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of mTOR				Bioorg Med Chem Lett 21: 1270-4 (2011) Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50336404 (4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...) Show SMILES Cc1cc(C(=O)Nc2ccn[nH]2)c2nc(C)nc(N)c2c1 Show InChI InChI=1S/C14H14N6O/c1-7-5-9-12(17-8(2)18-13(9)15)10(6-7)14(21)19-11-3-4-16-20-11/h3-6H,1-2H3,(H2,15,17,18)(H2,16,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha by fluorescene polarization assay				Bioorg Med Chem Lett 21: 1270-4 (2011) Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50336404 (4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...) Show SMILES Cc1cc(C(=O)Nc2ccn[nH]2)c2nc(C)nc(N)c2c1 Show InChI InChI=1S/C14H14N6O/c1-7-5-9-12(17-8(2)18-13(9)15)10(6-7)14(21)19-11-3-4-16-20-11/h3-6H,1-2H3,(H2,15,17,18)(H2,16,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha-phosphorylation at S473 residue in human BT20 cells				Bioorg Med Chem Lett 21: 1270-4 (2011) Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M
					More data for this Ligand-Target Pair