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BDBM50338682 (R/S)-3-chloro-N-((3S)-1-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-2-oxopyrrolidin-3-yl)-1H-indole-6-sulfonamide::CHEMBL1684190

SMILES: Fc1cc(ccc1N1CC[C@H](NS(=O)(=O)c2ccc3c(Cl)c[nH]c3c2)C1=O)C1CCCN1

InChI Key: InChIKey=ZNPDOYMGSIHJPU-GGYWPGCISA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50338682   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM50338682
PNG
((R/S)-3-chloro-N-((3S)-1-(2-fluoro-4-(pyrrolidin-2...)
Show SMILES Fc1cc(ccc1N1CC[C@H](NS(=O)(=O)c2ccc3c(Cl)c[nH]c3c2)C1=O)C1CCCN1 |r|
Show InChI InChI=1S/C22H22ClFN4O3S/c23-16-12-26-20-11-14(4-5-15(16)20)32(30,31)27-19-7-9-28(22(19)29)21-6-3-13(10-17(21)24)18-2-1-8-25-18/h3-6,10-12,18-19,25-27H,1-2,7-9H2/t18?,19-/m0/s1
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PC cid
PC sid
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Article
PubMed
2n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of factor 10a activity measured using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrate


Bioorg Med Chem Lett 21: 1582-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.131
BindingDB Entry DOI: 10.7270/Q28052WG
More data for this
Ligand-Target Pair