BDBM50340124 CHEMBL1760038::N4-methyl-N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

SMILES: COc1cc(Nc2nccc(n2)N(C)c2cnc3ccccc3c2)cc(OC)c1OC

InChI Key: InChIKey=NLRRRNUODSXMMS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340124   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50340124 (CHEMBL1760038 | N4-methyl-N4-(quinolin-3-yl)-N2-(3...) Show SMILES COc1cc(Nc2nccc(n2)N(C)c2cnc3ccccc3c2)cc(OC)c1OC Show InChI InChI=1S/C23H23N5O3/c1-28(17-11-15-7-5-6-8-18(15)25-14-17)21-9-10-24-23(27-21)26-16-12-19(29-2)22(31-4)20(13-16)30-3/h5-14H,1-4H3,(H,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	725	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human IGF1R				Bioorg Med Chem Lett 21: 2394-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D
					More data for this Ligand-Target Pair