Found 4 hits for monomerid = 503412 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human)) | BDBM503412
![PNG](/data/jpeg/tenK50/BindingDB_503412.png) ((4M)-2-(4-amino-4-methylpiperidin-1- yl)-5-(2-chlo...)Show SMILES COc1c(F)ccc(c1Cl)-c1c(C)nc(nc1C(N)=O)N1CCC(C)(N)CC1 |(-2.67,5.36,;-4,4.59,;-4,3.05,;-5.33,2.28,;-6.67,3.05,;-5.33,.74,;-4,-.03,;-2.67,.74,;-2.67,2.28,;-1.33,3.05,;-1.33,-.03,;,.74,;,2.28,;1.33,-.03,;1.33,-1.57,;,-2.34,;-1.33,-1.57,;-2.67,-2.34,;-2.67,-3.88,;-4,-1.57,;2.67,-2.34,;2.67,-3.88,;4,-4.65,;5.33,-3.88,;5.73,-5.36,;6.67,-3.11,;5.33,-2.34,;4,-1.57,)| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2930X9N |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human)) | BDBM503412
![PNG](/data/jpeg/tenK50/BindingDB_503412.png) ((4M)-2-(4-amino-4-methylpiperidin-1- yl)-5-(2-chlo...)Show SMILES COc1c(F)ccc(c1Cl)-c1c(C)nc(nc1C(N)=O)N1CCC(C)(N)CC1 |(-2.67,5.36,;-4,4.59,;-4,3.05,;-5.33,2.28,;-6.67,3.05,;-5.33,.74,;-4,-.03,;-2.67,.74,;-2.67,2.28,;-1.33,3.05,;-1.33,-.03,;,.74,;,2.28,;1.33,-.03,;1.33,-1.57,;,-2.34,;-1.33,-1.57,;-2.67,-2.34,;-2.67,-3.88,;-4,-1.57,;2.67,-2.34,;2.67,-3.88,;4,-4.65,;5.33,-3.88,;5.73,-5.36,;6.67,-3.11,;5.33,-2.34,;4,-1.57,)| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2JS9VKW |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human)) | BDBM503412
![PNG](/data/jpeg/tenK50/BindingDB_503412.png) ((4M)-2-(4-amino-4-methylpiperidin-1- yl)-5-(2-chlo...)Show SMILES COc1c(F)ccc(c1Cl)-c1c(C)nc(nc1C(N)=O)N1CCC(C)(N)CC1 |(-2.67,5.36,;-4,4.59,;-4,3.05,;-5.33,2.28,;-6.67,3.05,;-5.33,.74,;-4,-.03,;-2.67,.74,;-2.67,2.28,;-1.33,3.05,;-1.33,-.03,;,.74,;,2.28,;1.33,-.03,;1.33,-1.57,;,-2.34,;-1.33,-1.57,;-2.67,-2.34,;-2.67,-3.88,;-4,-1.57,;2.67,-2.34,;2.67,-3.88,;4,-4.65,;5.33,-3.88,;5.73,-5.36,;6.67,-3.11,;5.33,-2.34,;4,-1.57,)| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2JS9VKW |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human)) | BDBM503412
![PNG](/data/jpeg/tenK50/BindingDB_503412.png) ((4M)-2-(4-amino-4-methylpiperidin-1- yl)-5-(2-chlo...)Show SMILES COc1c(F)ccc(c1Cl)-c1c(C)nc(nc1C(N)=O)N1CCC(C)(N)CC1 |(-2.67,5.36,;-4,4.59,;-4,3.05,;-5.33,2.28,;-6.67,3.05,;-5.33,.74,;-4,-.03,;-2.67,.74,;-2.67,2.28,;-1.33,3.05,;-1.33,-.03,;,.74,;,2.28,;1.33,-.03,;1.33,-1.57,;,-2.34,;-1.33,-1.57,;-2.67,-2.34,;-2.67,-3.88,;-4,-1.57,;2.67,-2.34,;2.67,-3.88,;4,-4.65,;5.33,-3.88,;5.73,-5.36,;6.67,-3.11,;5.33,-2.34,;4,-1.57,)| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2930X9N |
More data for this Ligand-Target Pair | |