BDBM50342276 (2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl)methanone::CHEMBL1767090::US9725430, Compound 1j::US9962362, Compound 1j
SMILES: CCc1oc2ccc(O)cc2c1C(=O)c1ccc(O)cc1
InChI Key: InChIKey=CGUSGHJDNCSDGH-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM50342276 ((2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Anschutz Medical Campus Curated by ChEMBL | Assay Description Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou... | J Med Chem 54: 2701-13 (2011) Article DOI: 10.1021/jm1015022 BindingDB Entry DOI: 10.7270/Q2P26ZDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human)) | BDBM50342276 ((2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GNF | Assay Description The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut... | Bioorg Med Chem Lett 16: 5488-92 (2006) BindingDB Entry DOI: 10.7270/Q2ZK5JZ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human)) | BDBM50342276 ((2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CHILDREN HOSPITAL MEDICAL CENTER US Patent | Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003)).... | US Patent US9725430 (2017) BindingDB Entry DOI: 10.7270/Q23F4RSZ | |||||||||||
More data for this Ligand-Target Pair |